1-(4-氯苯基)-1,4-己二酮合成路线 （共 4 条）
反应条件
1: With triethylamine; zinc(II) chloride; tert-butyl alcohol in benzene
T=20°C; 2 h;
2: para-chloroacetophenone; 1-bromo-butan-2-one in benzene
T=20°C; 96 h;
参考文献
LUPIN LIMITED
Patent: WO2004/26828 A1, 2004 ;
Location in patent: Page 26-27 ;
反应条件
1: diiodomethane With diethylzinc; trifluoroacetic acid in dichloromethane
T=0°C; 0.5 h;
2: 1-(4-chlorophenyl)pentane-1,3-dione in dichloromethane
T=20°C; 5 h;
参考文献
Xue, Song; Li, Le-Zhen; Liu, Yong-Kang; Guo, Qing-Xiang
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 215 - 218
反应条件
1: vinyl ethyl ketone With indium(III) chloride; indium in water; acetonitrile
T=20°C; 24 h;
2: 4-chloro-benzoyl chloride With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
24 h; Reflux;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Cheong, Hao-Lun; Wong, Colin Hong An; Lai, Yin-Chang; Yang, Yong-Sheng; Loh, Teck-Peng
Journal of the American Chemical Society, 2010 , vol. 132, # 45 p. 15852 - 15855
反应条件
1: With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine
Stetter reaction; 0.25 h; Microwave irradiation;
2: With hydrogenchloride in water
参考文献
Biava, Mariangela; Porretta, Giulio C.; Poce, Giovanna; De Logu, Alessandro; Meleddu, Rita; De Rossi, Edda; Manetti, Fabrizio; Botta, Maurizio
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 11 p. 4734 - 4738
