(S)-3-(4-氨基苯基)-2-((叔丁氧基羰基)氨基)丙酸乙酯合成路线 （共 7 条）
参考文献
Ube Industries, Ltd.
Patent: US6265418 B1, 2001 ;
反应条件
hydrogen; ammonium formate; palladium on activated charcoal in methanol
1 h; Ambient temperature;
参考文献
Kupczyk-Subotkowska, Lidia; Siahaan, Teruna J.; Basile, Anthony S.; Friedman, Henry S.; Higgins, Patricia E.; Song, Di; Gallo, James M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1726 - 1730
反应条件
1: 80 percent / triethylamine / CH2Cl2 / 4 h / Ambient temperature
2: 100 percent / H2, ammonium formate / 10percent Pd/C / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Kupczyk-Subotkowska, Lidia; Siahaan, Teruna J.; Basile, Anthony S.; Friedman, Henry S.; Higgins, Patricia E.; Song, Di; Gallo, James M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1726 - 1730
反应条件
1: 80 percent / triethylamine / CH2Cl2 / 4 h / Ambient temperature
2: 100 percent / H2, ammonium formate / 10percent Pd/C / methanol / 1 h / Ambient temperature
View Scheme
参考文献
Kupczyk-Subotkowska, Lidia; Siahaan, Teruna J.; Basile, Anthony S.; Friedman, Henry S.; Higgins, Patricia E.; Song, Di; Gallo, James M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 11 p. 1726 - 1730
反应条件
1: 83 percent / KF / dimethylformamide / Ambient temperature
2: H2 / 10percent Pd/C / acetic acid; methanol / 4 h / ice-cooling
View Scheme
参考文献
Sasaki; Akutsu; Matsui; Suzuki; Sakurada; Sato; Kisara
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4435 - 4443
反应条件
in 2-ethoxy-ethanol
T=100 - 120°C; 1.25 h;
参考文献
CELLTECH R and D LIMITED
Patent: WO2004/7494 A1, 2004 ;
Location in patent: Page 16-17 ;
反应条件
in 2-ethoxy-ethanol
T=100 - 120°C; 1.25 h;
参考文献
CELLTECH R and D LIMITED
Patent: WO2004/7494 A1, 2004 ;
Location in patent: Page 16-17 ;
