1: 2-bromoacetaldehyde diethyl acetal With hydrogenchloride in 1,4-dioxane; water 0.5 h; Heating / reflux; 2: 5-bromo-pyridine-2,3-diamine With sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; 14 h; Heating / reflux;

in isopropyl alcohol T=20°C; RefluxInert atmosphere;

potassium carbonate

1: With zinc(II) chloride in methanol T=20°C; 1 h; 2: With sodium cyanoborohydride in methanol 14 h; Heating / reflux;