2-溴-1-(5-溴-2-甲氧基苯基)乙酮合成路线 （共 4 条）
反应条件
1: 2.) 10percent Pd/C / 1.) 2-propanol, 80 deg C, 1.5 h, 2.) CHCl3, 30 min 2: H2, Et3N / 10percent Pd/C / tetrahydrofuran / 5 h View Scheme
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
bromine in diethyl ether
1 h;
参考文献
Iradyan, M. A.; Aroyan, R. A.; Engoyan, A. P.; Pogosyan, A. V.; Stepanyan, G. M.; et al.
Pharmaceutical Chemistry Journal, 1990 , vol. 24, # 7 p. 481 - 485
Khimiko-Farmatsevticheskii Zhurnal, 1990 , vol. 24, # 7 p. 38 - 41
反应条件
N-bromosuccinmide in methanol
Ambient temperature;
参考文献
Rosen; Seeger; McLean; Nagel; Ives; Guarino; Bryce; Furman; Roth; Chalabi; Windels
Journal of Medicinal Chemistry, 1990 , vol. 33, # 11 p. 3020 - 3023
反应条件
1: K2CO3 / acetone / 3 h / Heating
2: Br2; AlCl3 / diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Cordera-Vargas, Alejandro; Quiclet-Sire, Beatrice; Zard, Samir Z.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 24 p. 4432 - 4443
