(+/-)-1-苯基-3-氮杂双环环[3.1.0]己烷合成路线 （共 6 条）
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in benzene
2 h; Heating;
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
sodium hydroxide in hydrogenchloride; benzene
参考文献
American Cyanamid Company
Patent: US4435419 A1, 1984 ;
反应条件
1: 85 percent / urea / xylene / Heating
2: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 80 percent / KOH / ethanol; H2O / 6 h / Heating
2: 85 percent / urea / xylene / Heating
3: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 85 percent / NBS, 48percent aq. HBr / CCl4 / Heating
2: 53 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
3: 80 percent / KOH / ethanol; H2O / 6 h / Heating
4: 85 percent / urea / xylene / Heating
5: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
反应条件
1: 53 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
2: 80 percent / KOH / ethanol; H2O / 6 h / Heating
3: 85 percent / urea / xylene / Heating
4: 34 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
