4-[[4-(3,4-二氯苯氧基)-1-哌啶基]甲基]-1,2-环戊烷二醇合成路线 （共 4 条）
反应条件
1: With borane in tetrahydrofuran
1.5 h; Heating / reflux;
2: in tetrahydrofuran; methanol
Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2004/87659 A1, 2004 ;
Location in patent: Page 28 ;
WO 2004/087659 A1
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C
2: K2OsO4*2H2O; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C
3: borane-THF / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Barton, Patrick; Caffrey, Moya V.; Linannen, Tero; Luckhurst, Christopher A.; Mochel, Tobias; Perry, Matthew W. D.; Springthorpe, Brian; Stein, Linda; Bahl, Ash; Bowers, Keith; Gilmour, Peter; Hawley, Shaun; Denton, Rebecca; Riley, Robert J.; Roe, Emma; Webborn, Peter
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6694 - 6699,6
反应条件
1: K2OsO4*2H2O; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C
2: borane-THF / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Barton, Patrick; Caffrey, Moya V.; Linannen, Tero; Luckhurst, Christopher A.; Mochel, Tobias; Perry, Matthew W. D.; Springthorpe, Brian; Stein, Linda; Bahl, Ash; Bowers, Keith; Gilmour, Peter; Hawley, Shaun; Denton, Rebecca; Riley, Robert J.; Roe, Emma; Webborn, Peter
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6694 - 6699,6
反应条件
1: triethylamine / dichloromethane / 2 h / 0 °C
2: K2OsO4*2H2O; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C
3: borane-THF / tetrahydrofuran / 2 h / |Reflux
View Scheme
参考文献
Barton, Patrick; Caffrey, Moya V.; Linannen, Tero; Luckhurst, Christopher A.; Mochel, Tobias; Perry, Matthew W. D.; Springthorpe, Brian; Stein, Linda; Bahl, Ash; Bowers, Keith; Gilmour, Peter; Hawley, Shaun; Denton, Rebecca; Riley, Robert J.; Roe, Emma; Webborn, Peter
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 21 p. 6694 - 6699,6
