(R)-N-乙酰基-beta-苯丙氨酸甲酯合成路线 （共 25 条）
反应条件
hydrogen; [Rh((S,S,S)-binapine)(3,5-norbornadiene)]SbF6 in tetrahydrofuran T=20°C; P=1034.3 Torr; 24 h;
参考文献
Angewandte Chemie - International Edition, , vol. 42, # 30 p. 3509 - 3511
反应条件
hydrogen; [Rh{(R,R)-(Et-FerroTANE)}(MeOH)2]BF4 in methanol T=25°C; P=750.06 Torr;
参考文献
Angewandte Chemie - International Edition, , vol. 42, # 8 p. 913 - 916
反应条件
hydrogen; [Rh(norbornadiene)(1-[(2R,5R)-2,5-dimethylphospholano]-2-diphenylphosphinobenzene)][BF4] in dichloromethane P=3750.3 Torr; 3 h; Product distribution; Further Variations:Solvents;
参考文献
Dalton Transactions, , # 12 p. 1901 - 1905
反应条件
1.1: NH4OAc / methanol 1.2: pyridine / tetrahydrofuran / Heating 2.1: H2 / [Rh((S,S,S)-binapine)(3,5-norbornadiene)]SbF6 / tetrahydrofuran / 24 h / 20 °C / 1034.3 Torr View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 42, # 30 p. 3509 - 3511
反应条件
triethylamine in chloroform T=0 - 20°C; optical yield given as percent ee;
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
反应条件
Ru(OCOCH3)2((R)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl); hydrogen in methanol T=25°C; P=3040 Torr; 100 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 2, # 7 p. 543 - 554
反应条件
Candida antarctica lipase B (Novozym 435) in diethyl ether T=23°C; 106 h; Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 8, # 24 p. 5593 - 5596
反应条件
Carica papaya lipase in hexane T=45°C; Resolution of racemateEnzymatic reaction;
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1: N-((S)-1-phenylbut-3-enyl)acetamide With ozone in methanol 2: With periodic acid 3: diazomethyl-trimethyl-silane Further stages.;
参考文献
Journal of Organic Chemistry, , vol. 66, # 4 p. 1283 - 1286
反应条件
1: pyridine / tetrahydrofuran / 24 h / Heating 2: H2, Ru(OCOCH3)2<(R)-binap> / methanol / 100 h / 25 °C / 3040 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 2, # 7 p. 543 - 554
