(R)-N-乙酰基-beta-苯丙氨酸甲酯合成路线 （共 25 条）
反应条件
1: AcCl / 16 h 2: NH4OAc / methanol / 120 h / Ambient temperature 3: pyridine / tetrahydrofuran / 24 h / Heating 4: H2, Ru(OCOCH3)2<(R)-binap> / methanol / 100 h / 25 °C / 3040 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 2, # 7 p. 543 - 554
反应条件
1.1: sodium hydroxide / water / 8 h / 40 °C / pH 11 2.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / |Cooling with ice 2.2: 20 °C 3.1: thionyl chloride / 24 h / 20 °C 3.2: 24 h / 0 °C 4.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1.1: thionyl chloride / 24 h / 20 °C 1.2: 24 h / 0 °C 2.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1.1: ammonium acetate / ethanol / 12 h / |Reflux 2.1: sodium hydroxide / water / 8 h / 40 °C / pH 11 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / |Cooling with ice 3.2: 20 °C 4.1: thionyl chloride / 24 h / 20 °C 4.2: 24 h / 0 °C 5.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / dichloromethane / |Cooling with ice 1.2: 20 °C 2.1: thionyl chloride / 24 h / 20 °C 2.2: 24 h / 0 °C 3.1: Carica papaya lipase / hexane / 45 °C / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , # 3 p. 557 - 565
反应条件
1: ammonium acetate / methanol / 72 h / 20 °C 2: pyridine / tetrahydrofuran / |Reflux 3: hydrogen; Pd/Al2O3; (1S,3R,4S,8R,9R)-9-hydroxy-cinchonane; benzylamine / isopropyl alcohol / 4 h / 25 °C / 15001.5 Torr / |Autoclave View Scheme
参考文献
Journal of Molecular Catalysis A: Chemical, , vol. 379, p. 117 - 121
反应条件
1: pyridine / tetrahydrofuran / |Reflux 2: hydrogen; Pd/Al2O3; (1S,3R,4S,8R,9R)-9-hydroxy-cinchonane; benzylamine / isopropyl alcohol / 4 h / 25 °C / 15001.5 Torr / |Autoclave View Scheme
参考文献
Journal of Molecular Catalysis A: Chemical, , vol. 379, p. 117 - 121
反应条件
1: (S)-(2-(bis(3,3-dimethylphenyl)(hydroxy)methyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone; trichlorosilane / chloroform / 48 h / -30 °C 2: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 3: triethylamine / chloroform / 0 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 14, # 32 p. 9864 - 9867
反应条件
1: sodium hydride / toluene / Reflux 2: toluene-4-sulfonic acid / methanol / Reflux 3: (S)-(2-(bis(3,3-dimethylphenyl)(hydroxy)methyl)pyrrolidin-1-yl)(pyridin-2-yl)methanone; trichlorosilane / chloroform / 48 h / -30 °C 4: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 5: triethylamine / chloroform / 0 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 14, # 32 p. 9864 - 9867
反应条件
1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C 2: triethylamine / chloroform / 0 - 20 °C View Scheme
参考文献
Chemistry - A European Journal, , vol. 14, # 32 p. 9864 - 9867
