3-[(4-乙氧基-1,4-二氧代丁基)氨基]-2-吡啶羧酸乙酯合成路线 （共 4 条）
反应条件
pyridine in toluene 2 h; Heating;
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
反应条件
potassium hydride in N,N-dimethyl-formamide; toluene T=70°C;
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
反应条件
1: 43 percent / KH / toluene; dimethylformamide / 70 °C 2: 95 percent / H2O / dimethylformamide / 150 °C View Scheme
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
反应条件
1: 43 percent / KH / toluene; dimethylformamide / 70 °C
2: 95 percent / H2O / dimethylformamide / 150 °C
3: 75 percent / HCl; NaOAc / acetic acid / 70 °C
View Scheme
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
