5H-吡啶并[3,2-b]氮杂卓-6,9-(7H,8H)-二酮合成路线 （共 5 条）
反应条件
water in N,N-dimethyl-formamide T=150°C;
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
反应条件
1: 81 percent / pyridine / toluene / 2 h / Heating 2: 43 percent / KH / toluene; dimethylformamide / 70 °C 3: 95 percent / H2O / dimethylformamide / 150 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 413 - 416
反应条件
1: 43 percent / KH / toluene; dimethylformamide / 70 °C 2: 95 percent / H2O / dimethylformamide / 150 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 413 - 416
反应条件
hydrogenchloride; sodium acetate in acetic acid
T=70°C;
参考文献
Kunick, Conrad; Lauenroth, Kathrin; Leost, Maryse; Meijer, Laurent; Lemcke, Thomas
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 413 - 416
反应条件
sodium acetate; acetic acid
T=70°C;
参考文献
Stukenbrock, Hendrik; Mussmann, Rainer; Geese, Marcus; Ferandin, Yoan; Lozach, Olivier; Lemcke, Thomas; Kegel, Simone; Lomow, Alexander; Burk, Ulrike; Dohrmann, Cord; Meijer, Laurent; Austen, Matthias; Kunick, Conrad
Journal of Medicinal Chemistry, 2008 , vol. 51, # 7 p. 2196 - 2207
