3-氰基-4-氟苯甲酸甲酯合成路线 （共 6 条）
反应条件
triethylamine; triphenylphosphine; palladium diacetate in acetonitrile T=60°C; P=3102.97 Torr; 96 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/67529 A1, 2004 ;
Location in patent: Page 193 - 194 ;
WO 2004/067529 A1
反应条件
thionyl chloride T=0°C; 3 h; Heating / reflux;
参考文献
SoftCure Pharmaceuticals AB
Patent: WO2008/152142 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 3-cyano-4-fluorobenzoic acid With potassium carbonate in N,N-dimethyl-formamide 0.166667 h; 2: methyl iodide in N,N-dimethyl-formamide 1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; HADIDA-RUAH, Sara, Sabina; ARUMUGAM, Vijayalaksmi; DENINNO, Michael, Paul; FRIEMAN, Bryan, A.; KALLEL, Edward, Adam; MILLER, Mark, Thomas; UY, Johnny; ZHOU, Jinglan
Patent: WO2013/109521 A1, 2013 ;
Location in patent: Paragraph 00287; 00288 ;
参考文献
Bayer Schering Pharma Aktiengesellschaft
Patent: EP1897885 A1, 2008 ;
反应条件
1: 80 percent / pyridinium dichromate / dimethylformamide / 20 °C 2: 82 percent / acetyl chloride / 48 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 6 p. 1339 - 1350
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 20 °C / Cooling with ice 1.2: 16 h / 50 °C 2.1: sodium hydroxide; water / isopropyl alcohol / 20 °C 2.2: pH ~ 2 View Scheme
参考文献
GLAXO WELLCOME HOUSE
Patent: US2012/283297 A1, 2012 ;
