二氮杂螺[4.5]癸烷-2-羧酸-1(2H)-羧酸合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=60°C; P=3750.38 Torr; 12 h;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/97794 A1, 2005 ;
Location in patent: Page/Page column 43 ;
WO 2005/097794 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol
参考文献
WO2012/177782 A1, ;
Page/Page column 108 ;
WO 2012/177782 A1
反应条件
1.1: trifluoroacetic acid / toluene; acetonitrile / 20 - 50 °C 1.2: 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C 2.2: 4 h 3.1: hydrogen / palladium 10 on activated carbon / methanol View Scheme
参考文献
WO2012/177782 A1, ;
WO 2012/177782 A1
反应条件
1.1: trifluoroacetic acid / toluene; acetonitrile / 20 - 50 °C 1.2: 0 - 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C 2.2: 4 h 3.1: hydrogen / palladium 10 on activated carbon / methanol View Scheme
参考文献
WO2012/177782 A1, ;
WO 2012/177782 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C 1.2: 4 h 2.1: hydrogen / palladium 10 on activated carbon / methanol View Scheme
参考文献
WO2012/177782 A1, ;
WO 2012/177782 A1
