N-乙酰基-2-氯-2-脱氧神经氨酸甲酯4,7,8,9-四乙酸酯合成路线 （共 51 条）
反应条件
methanesulfonic acid T=60°C; 24 h;
参考文献
Yu, Chung-Shan; Niikura, Kenichi; Lin, Chun-Cheng; Wong, Chi-Huey
Angewandte Chemie - International Edition, 2001 , vol. 40, # 15 p. 2900 - 2903
反应条件
Ag2CO3; molecular sieve in acetonitrile 3 h; Ambient temperature;
参考文献
Baggett; Marsden
Carbohydrate research, 1982 , vol. 110, # 1 p. 11 - 18
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 3 h; Ambient temperature;
参考文献
Synlett, , # 5 p. 479 - 482
反应条件
1: 7-Hydroxy-4-(trifluoromethyl)-coumarin With sodium hydroxide 2: methyl 5-acetamido-4,7,8,9-tetra-OAc-2-chloro-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosylonate in N,N-dimethyl-formamide T=20°C; 4 h; Further stages.;
参考文献
Buchini, Sabrina; Buschiazzo, Alejandro; Withers, Stephen G.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 14 p. 2700 - 2703
反应条件
disodium hydrogenphosphate in acetonitrile 3 h; Heating;
参考文献
Kulikova, Nadezhda Yu.; Shpirt, Anna M.; Kononov, Leonid O.
Synthesis, 2006 , # 24 p. 4113 - 4114
反应条件
silver carbonate in dichloromethane T=30°C; 168 h; Molecular sieves 3A;
参考文献
INALCO S.P.A.; TAMERLANI, Giancarlo; LOMBARDI, Ilaria; BARTALUCCI, Debora; DANESI, Andrea; SALSINI, Liana; MANONI, Marco; CIPOLLETTI, Giovanni
Patent: WO2010/116317 A1, 2010 ;
Location in patent: Page/Page column 20-21 ;
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile 3 h; Ambient temperature;
参考文献
Synlett, , # 5 p. 479 - 482
反应条件
Ag2CO3 in dichloromethane -20 deg C 15 hour, room temp. 50 hour.; Title compound not separated from byproducts;
参考文献
Carbohydrate Research, , vol. 125, p. 47 - 64
反应条件
4 A molecular sieve; mercury(II) cyanide; mercury dibromide in dichloromethane T=20°C; 48 h; Further byproducts given;
参考文献
Carbohydrate Research, , vol. 163, p. 209 - 226
反应条件
mercury(II) cyanide; mercury dibromide in dichloromethane 96 h; Ambient temperature;
参考文献
Carbohydrate Research, , vol. 125, p. 47 - 64
