Pd-montmorillonite in ethanol T=80°C; 15 h;

triethyl borane; potassium hexamethylsilazane; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; palladium diacetate in tetrahydrofuran T=50°C; 2 h;

(L)-valine methyl ester; 4-[bis(2-diphenylphosphanyl)ethyl]amino-4-oxobutanoic acid; sodium hydride; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran T=-30°C; var. of reagent, catalyst, temp.; asymmetric induction; Product distribution;

sodium hydroxide in water 2 h; Ambient temperaturepH 10.8; Title compound not separated from byproducts;

Pd catalyst