5-羟基-2-甲基苯并呋喃合成路线 （共 7 条）
反应条件
palladium 10 on activated carbon; hydrogen in tetrahydrofuran
T=20°C; P=2585.81 Torr; Inert atmosphere;
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
Location in patent: Page/Page column 25; 27 ;
反应条件
boron tribromide in dichloromethane
T=20°C; Cyclization; demethylation; 1 h;
参考文献
Dupont, Romain; Cotelle, Philippe
Synthesis, 1999 , # 9 p. 1651 - 1655
反应条件
1.1: potassium carbonate / acetonitrile / |Reflux
2.1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
3.1: potassium carbonate / acetonitrile / 60 h / |Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
5.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
5.2: 20 °C
6.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1.1: MgBr2(Et2O) / benzene; diethyl ether / |Inert atmosphere; |Reflux
2.1: potassium carbonate / acetonitrile / 60 h / |Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
4.2: 20 °C
5.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1.1: potassium carbonate / acetonitrile / 60 h / |Reflux
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
3.2: 20 °C
4.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
2.2: 20 °C
3.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0 °C / |Inert atmosphere
1.2: 20 °C
2.1: hydrogen; palladium 10 on activated carbon / tetrahydrofuran / 20 °C / 2585.81 Torr / |Inert atmosphere
View Scheme
参考文献
THE UNIVERSITY OF NOTTINGHAM; MISTRY, Shailesh; DARAS, Etienne; FROMONT, Christophe; JADHAV, Gopal; FISCHER, Peter Martin; KELLAM, Barrie; HILL, Stephen John; BAKER, Jillian Glenda
Patent: WO2013/121209 A1, 2013 ;
