1: N-(carbobenzyloxy)-glycine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 2 h; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran T=35°C; 3: With hydrogenchloride in tetrahydrofuran; water; ethyl acetate

1: tetrahydrofuran / 12 h / Ambient temperature 2: 1.) propan-2-ylmagnesium bromide / 1.) THF, r.t., 0.5 h; r.t. to 40 deg C, 0.5 h, 2.) THF, r.t., 4 h View Scheme

1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride T=20°C; 4 h; 2: N-Benzyloxycarbonylglycine imidazolide T=20°C; 16 h;

iso-propylmagnesium bromide 1.) THF, r.t., 0.5 h; r.t. to 40 deg C, 0.5 h, 2.) THF, r.t., 4 h; Yield givenMultistep reaction;

(i) 1H,1'H-1,1'-sulfinyl-bis-imidazole, THF, (ii) /BRN= 4163159/, Et2O; Multistep reaction;