3-氯-2,5-二乙基吡嗪合成路线 （共 8 条）
反应条件
anhydrous tetramethylammonium chloride; trichlorophosphate in 1,4-dioxane T=20 - 75°C;
参考文献
Pfizer Inc
Patent: US2005/107610 A1, 2005 ;
Location in patent: Page/Page column 2 ;
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 15 h; Yield given. Yields of byproduct given;
参考文献
Akita, Yasuo; Noguchi, Tomofumi; Sugimoto, Michinobu; Ohta, Akihiro
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1481 - 1485
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=100°C; 15 h; Yield given. Yields of byproduct given;
参考文献
Akita, Yasuo; Noguchi, Tomofumi; Sugimoto, Michinobu; Ohta, Akihiro
Journal of Heterocyclic Chemistry, 1986 , vol. 23, p. 1481 - 1485
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane; hexane 2 h; Heating;
参考文献
Ohta, Akihiro; Inoue, Akira; Watanabe, Tokuhiro
Heterocycles, 1984 , vol. 22, # 10 p. 2317 - 2321
反应条件
potassium acetate; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide
T=100°C; 2 h;
参考文献
Akita, Yasuo; Inoue, Akira; Ohta, Akihiro
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 4 p. 1447 - 1458
反应条件
benzamide; potassium carbonate
T=180 - 230°C; 1 h;
参考文献
Watanabe, Tokuhiro; Kikuchi, Etsuko; Tamura, Wataru; Akita, Yasuo; Tsutsui, Mayumi; Ohta, Akihiro
Heterocycles, 1980 , vol. 14, # 3 p. 287 - 290
反应条件
potassium carbonate
14 h; Heating;
参考文献
Watanabe, Tokuhiro; Kikuchi, Etsuko; Tamura, Wataru; Akita, Yasuo; Tsutsui, Mayumi; Ohta, Akihiro
Heterocycles, 1980 , vol. 14, # 3 p. 287 - 290
反应条件
sodium azide in N,N-dimethyl-formamide
10 h; Heating;
参考文献
Watanabe, T.; Nishiyama, J.; Hirate, R.; Uehara, K.; Inoue, M.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1277 - 1281
