3-氨基-5-(2-甲基-2-丙基)-2-噻吩甲腈合成路线 （共 2 条）
反应条件
sodium hydroxide in ethanol; water 1 h; Reflux;
参考文献
KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED; GOKARAJU, Ganga Raju; KASINA, Sudhakar; SOMEPALLI, Venkateswarlu; GOKARAJU, Rama Raju; GOKARAJU, Venkata Kanaka Ranga Raju; BHUPATHIRAJU, Kiran; GOLAKOTI, Trimurtulu; SENGUPTA, Krishanu; ALLURI, Venkata Krishna Raju
Patent: WO2012/77135 A2, 2012 ;
Location in patent: Page/Page column 76 ;
WO 2012/077135 A2
反应条件
1: 3-chloro-4,4-dimethylpent-2-enenitrile With sodium sulfide in N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
2: chloroacetonitrile in N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
3: With sodium methylate in methanol; N,N-dimethyl-formamide
T=70 - 80°C; 2 h;
参考文献
KASINA LAILA INNOVA PHARMACEUTICALS PRIVATE LIMITED; GOKARAJU, Ganga Raju; KASINA, Sudhakar; SOMEPALLI, Venkateswarlu; GOKARAJU, Rama Raju; GOKARAJU, Venkata Kanaka Ranga Raju; BHUPATHIRAJU, Kiran; GOLAKOTI, Trimurtulu; SENGUPTA, Krishanu; ALLURI, Venkata Krishna Raju
Patent: WO2012/77135 A2, 2012 ;
Location in patent: Page/Page column 75-76 ;
WO 2012/077135 A2
