6-溴-1,2-苯并异噻唑-3-甲酸合成路线 （共 5 条）
反应条件
1: With water; sodium hydroxide in methanol Reflux; 2: With hydrogenchloride in methanol; water
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.
Patent: WO2009/89462 A1, 2009 ;
Location in patent: Page/Page column 81 ;
WO 2009/089462 A1
参考文献
WO2007/92751 A2, ;
Page/Page column 34 ;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/56582 A1, 2007 ;
Location in patent: Page/Page column 69 ;
WO 2007/056582 A1
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran; tert-butyl alcohol
T=65°C; 16 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2007/56582 A1, 2007 ;
Location in patent: Page/Page column 69-70 ;
WO 2007/056582 A1
反应条件
4-(N,N-dimethlyamino)pyridine in tetrahydrofuran
T=65°C; 16 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 62 ;
