4-(叔丁基)-2-氯苯甲腈合成路线 （共 3 条）
反应条件
1: 4-t-butyl-2-chloroaniline With sulfuric acid; acetic acid; sodium nitrite in water
T=10°C; 1 h;
2: n-Bu4N+CN- With CuSO4‵5H2O; sodium hydrogencarbonate in water; toluene
T=55°C; 0.5 h; Inert atmosphere;
参考文献
PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca
Patent: WO2011/120604 A1, 2011 ;
Location in patent: Page/Page column 111; 112; 132 ;
WO 2011/120604 A1
反应条件
1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 - 20 °C
2.1: hydrogenchloride / water
3.1: sodium nitrite; sulfuric acid; acetic acid / water / 1 h / 10 °C
3.2: 0.5 h / 55 °C / Inert atmosphere
View Scheme
参考文献
PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca
Patent: WO2011/120604 A1, 2011 ;
WO 2011/120604 A1
反应条件
1.1: hydrogenchloride / water
2.1: sodium nitrite; sulfuric acid; acetic acid / water / 1 h / 10 °C
2.2: 0.5 h / 55 °C / Inert atmosphere
View Scheme
参考文献
PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca
Patent: WO2011/120604 A1, 2011 ;
WO 2011/120604 A1
