3-氨基-2,2-二甲基丙腈合成路线 （共 10 条）
反应条件
1: 2-hydroxy-pyridine; triethylamine / 24 h / 60 - 70 °C 2: sodium hydroxide; dihydrogen peroxide / water; ethanol / 30 - 40 °C 3: hydrogen; palladium 10 on activated carbon; ammonia / ethanol / 20 °C / 5250.53 Torr View Scheme
反应条件
methanol; nickel Hydrogenation;
参考文献
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
反应条件
1: 2-hydroxy-pyridine; triethylamine / 24 h / 60 - 70 °C 2: sodium hydroxide; dihydrogen peroxide / water; ethanol / 30 - 40 °C View Scheme
参考文献
MAYLAN LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; MITTAPELLY, Nagaraju; RAVI, Vijaya Krishna; SAIDUGARI, Swamy
Patent: WO2013/144979 A1, 2013 ;
反应条件
1: triethylamine; 2-hydroxy-pyridine / 30 h / 80 - 90 °C 2: sodium hydroxide; dihydrogen peroxide / water / 20 - 40 °C 3: hydrogen; ethanolamine / 5 palladium on charcoal / ethanol / 2206.72 Torr View Scheme
参考文献
MAYLAN LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; MITTAPELLY, Nagaraju; RAVI, Vijaya Krishna; SAIDUGARI, Swamy
Patent: WO2013/144979 A1, 2013 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol
72 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1847531 A1, 2007 ;
Location in patent: Page/Page column 51-52 ;
EP 1847531 A1
反应条件
1: With thionyl chloride in 1,2-dichloro-ethane
T=75 - 80°C; 5 h;
2: With trichlorophosphate in toluene
T=90 - 95°C;
3: With sodium hydroxide in water; toluene
T=10 - 15°C; pH=14;
参考文献
MATRIX LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; PALLA, Vijay Kumar; SAIDUGARI, Swamy; MITTAPELLY, Nagaraju; JALDU, Ravikanth; VIJAYA, Krishna Ravi; SESHADRI, Rao Manukonda; DASARL, Srinivasa Rao; SRINIVASA, Rao Potla; DANDALA, Ramesh
Patent: WO2012/52829 A1, 2012 ;
Location in patent: Page/Page column 11 ;
反应条件
hydrogenchloride; iron
T=60 - 70°C;
参考文献
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
反应条件
T=100°C; Hydrogenation;
参考文献
Imp.Chem.Ind.
Patent: US2428614 , 1945 ;
Full Text Show Details
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
参考文献
Imp.Chem.Ind.
Patent: US2428614 , 1945 ;
Full Text Show Details
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
参考文献
Imp.Chem.Ind.
Patent: US2428614 , 1945 ;
Full Text Show Details
Buckley; Heath; Rose
Journal of the Chemical Society, 1947 , p. 1502
Chem.Abstr., 1948 , p. 770
