6-氯咪唑并[1,2-b]哒嗪合成路线 (共 17 条)
反应条件
1: With N-bromosuccinmide in chloroform T=0 - 20°C; 2: With water; sodium hydrogencarbonate in chloroform; ethyl acetate
参考文献
US2009/93475 A1, ;
Page/Page column 6 ;
反应条件
1: nitric acid, sulfuric acid 2: 71 percent / SnCl2, conc. HCl aq. / H2O / 0.42 h / 20 - 100 °C View Scheme
参考文献
Kuwahara, Masaaki; Kawano, Yasuhiko; Shimazu, Hiroshi; Ashida, Yasuko; Miyake, Akio
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 122 - 131
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5145850 A1, 1992 ;
反应条件
1: With sodium acetate; acetic acid
Reflux;
2: pH=12;
参考文献
NOVARTIS AG; DAI, Miao; FU, Xingnian; HE, Feng; JIANG, Lei; LI, Yue; LIANG, Fang; LIU, Lei; MI, Yuan; XU, Yao-chang; XUN, Guoliang; YAN, Xiaoxia; YU, Zhengtian; ZHANG, Ji, Yue
Patent: WO2011/20861 A1, 2011 ;
Location in patent: Page/Page column 66 ;
反应条件
sodium chloride; sodium in N-methyl-acetamide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US4864022 A1, 1989 ;
反应条件
N-chloro-succinimide in chloroform
16 h;
参考文献
ALCON MANUFACTURING, LTD.
Patent: US2008/153813 A1, 2008 ;
Location in patent: Page/Page column 5 ;
US 20080153813 A1
反应条件
in tetrachloromethane; 1N-sodium hydroxide
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5155108 A1, 1992 ;