1-甲基-9h-吡啶并[3,4-b]吲哚-6-醇合成路线 （共 9 条）
反应条件
pyridine hydrochloride
T=215°C; 0.25 h;
参考文献
Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1994 , vol. 35, # 13 p. 2003 - 2004
反应条件
1: 73 percent / 2M K2CO3 / Pd(PPh3)4 / toluene; ethanol / 48 h / Heating
2: 69 percent / n-BuLi / tetrahydrofuran / -78 deg C, 1.5 h; 1 h
3: 81 percent / pyridinium chloride / 0.25 h / 215 °C
View Scheme
参考文献
Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1994 , vol. 35, # 13 p. 2003 - 2004
反应条件
Cunninghamella echinulata NRRL 3655 medium α in N,N-dimethyl-formamide
T=20°C; 336 h; microbial transformation;
参考文献
Herath, Wimal; Mikell, Julie Rakel; Ferreira, Daneel; Khan, Ikhlas Ahmad
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 646 - 648
反应条件
emulsin
T=37°C; 120 h; acetate buffer (pH 4.7);
参考文献
Aimi, Norio; Murakami, Hiroshi; Tsuyuki, Tadashi; Nishiyama, Tomoko; Sakai, Shin-ichiro; Haginiwa, Joju
Chemical & Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 3064 - 3066
反应条件
hydrogen bromide; acetic acid
T=130°C;
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: methanol; water / 12 h / 20 °C
2: HCl / 100 °C
3: cumene / Pd/C / Heating
4: HBr; CH3COOH / 130 °C
View Scheme
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: HCl / 100 °C
2: cumene / Pd/C / Heating
3: HBr; CH3COOH / 130 °C
View Scheme
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: cumene / Pd/C / Heating
2: HBr; CH3COOH / 130 °C
View Scheme
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: 69 percent / n-BuLi / tetrahydrofuran / -78 deg C, 1.5 h; 1 h
2: 81 percent / pyridinium chloride / 0.25 h / 215 °C
View Scheme
参考文献
Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy
Tetrahedron Letters, 1994 , vol. 35, # 13 p. 2003 - 2004
