(4S,5S,6R)-2,2,4-三甲基-7-亚甲基-1,3-二氧杂螺[4.4]壬烷-6-醇合成路线 （共 6 条）
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium; diethylaluminium chloride in toluene
T=0°C;
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
反应条件
1: DIBAL / CH2Cl2 / -78 °C
2: benzene / 60 °C
3: 86 percent / H2 / Pd/C / ethyl acetate
4: 70 percent / BuLi / tetrahydrofuran / -78 - 0 °C
5: mCPBA; NaHCO3 / CH2Cl2 / 20 °C
6: 67 percent / LiTMP; Et2AlCl / toluene / 0 °C
View Scheme
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
反应条件
1: benzene / 60 °C
2: 86 percent / H2 / Pd/C / ethyl acetate
3: 70 percent / BuLi / tetrahydrofuran / -78 - 0 °C
4: mCPBA; NaHCO3 / CH2Cl2 / 20 °C
5: 67 percent / LiTMP; Et2AlCl / toluene / 0 °C
View Scheme
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
反应条件
1: 86 percent / H2 / Pd/C / ethyl acetate
2: 70 percent / BuLi / tetrahydrofuran / -78 - 0 °C
3: mCPBA; NaHCO3 / CH2Cl2 / 20 °C
4: 67 percent / LiTMP; Et2AlCl / toluene / 0 °C
View Scheme
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
反应条件
1: 70 percent / BuLi / tetrahydrofuran / -78 - 0 °C
2: mCPBA; NaHCO3 / CH2Cl2 / 20 °C
3: 67 percent / LiTMP; Et2AlCl / toluene / 0 °C
View Scheme
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
反应条件
1: mCPBA; NaHCO3 / CH2Cl2 / 20 °C
2: 67 percent / LiTMP; Et2AlCl / toluene / 0 °C
View Scheme
参考文献
Ohira, Susumu; Fujiwara, Hiroyuki; Maeda, Kiyomi; Habara, Masaharu; Sakaedani, Naomi; Akiyama, Megumi; Kuboki, Atsuhito
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1639 - 1641
