(4-氰基-3-甲氧基苯基)硼酸合成路线 (共 1 条)
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran
T=-78°C; 0.5 h; Cooling with acetone-dry ice;
2: With hydrogenchloride in tetrahydrofuran; water
1 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED?
Patent: WO2005/95400 A1, 2005 ;
Location in patent: Page/Page column 341 ;
WO 2005/095400 A1