3-氨基-4,6-二甲基噻吩[2,3-b]吡啶-2-羧酰胺合成路线 （共 7 条）
反应条件
sodium methylate in methanol
Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2003/103661 A1, 2003 ;
Location in patent: Page 83 ;
WO 03/103661 A1
反应条件
hydrogenchloride in acetic acid
T=20°C; 2 h;
参考文献
Stroganova, Tatyana A.; Vasilin, Vladimir K.; Zelenskaya, Elena A.; Red'kin, Viktor M.; Krapivin, Gennady D.
Synthesis, 2008 , # 19 art. no. T02808SS, p. 3088 - 3098
反应条件
hydrogenchloride in acetic acid
T=20°C; 21 h;
参考文献
Stroganova, Tatyana A.; Vasilin, Vladimir K.; Zelenskaya, Elena A.; Red'kin, Viktor M.; Krapivin, Gennady D.
Synthesis, 2008 , # 19 art. no. T02808SS, p. 3088 - 3098
反应条件
sodium ethanolate in ethanol
1.5 h; Heating;
参考文献
Wagner; Vieweg; Leistner; Bohm; Krasselt; Hanfe ld; Prantz; Grupe
Pharmazie, 1990 , vol. 45, # 2 p. 102 - 109
反应条件
hydrogenchloride in acetic acid
T=50 - 60°C; 1 h;
参考文献
Stroganova, Tatyana A.; Vasilin, Vladimir K.; Zelenskaya, Elena A.; Red'kin, Viktor M.; Krapivin, Gennady D.
Synthesis, 2008 , # 19 art. no. T02808SS, p. 3088 - 3098
参考文献
Shevdov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1070 - 1074
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1331 - 1335
参考文献
Shevdov,V.I. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1979 , vol. 15, p. 1070 - 1074
Khimiya Geterotsiklicheskikh Soedinenii, 1979 , vol. 15, p. 1331 - 1335
