8-溴-1H-2-喹啉酮合成路线 （共 12 条）
反应条件
1: With AlCl3, aluminium chloride in chlorobenzene T=125°C; 2 h; 2: With water in chlorobenzene T=0°C;
参考文献
Cailleau, Nathalie; Davies, David Thomas; Esken, Joel Michael; Hennessy, Alan Joseph; Kusalakumari Sukumar, Senthil Kumar; Markwell, Roger Edward; Miles, Timothy James; Pearson, Neil David
Patent: US2008/221110 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
1: 92 percent / potassium carbonate / acetone; H2O / 2 h / 0 °C 2: 56 percent / aluminium chloride / chlorobenzene / 2 h / 125 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 8 p. 1559 - 1568
反应条件
phosphorus oxytribromide T=140°C; 3 h;
参考文献
Mao, Lisheng; Moriuchi, Toshiyuki; Sakurai, Hidehiro; Fujii, Hiroyuki; Hirao, Toshikazu
Tetrahedron Letters, 2005 , vol. 46, # 48 p. 8419 - 8422
反应条件
1: 8-bromo-1H-quinoline-2-one With potassium carbonate in N,N-dimethyl-formamide T=0°C; 0.25 h; 2: methyl iodide in N,N-dimethyl-formamide T=0 - 20°C; 3 h;
参考文献
Cailleau, Nathalie; Davies, David Thomas; Esken, Joel Michael; Hennessy, Alan Joseph; Kusalakumari Sukumar, Senthil Kumar; Markwell, Roger Edward; Miles, Timothy James; Pearson, Neil David
Patent: US2008/221110 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
potassium carbonate in dichloromethane; water; N,N-dimethyl-formamide
参考文献
GLAXO GROUP LIMITED
Patent: EP1980251 A1, 2008 ;
EP 1980251 A1
反应条件
1: trichlorophosphate / 2 h / 125 °C 2: methanol / 5 h / Reflux View Scheme
参考文献
Ullah, Nisar
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2012 , vol. 67, # 1 p. 75 - 84
反应条件
trichlorophosphate T=125°C; 2 h;
参考文献
Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred
European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568
反应条件
sodium hydroxide; dimethyl sulfate in methanol; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US4349554 A1, 1982 ;
反应条件
1: 84 percent / POBr3 / 3 h / 140 °C
2: 84 percent / K2CO3 / Pd(PPh3)4 / toluene; ethanol / 22 h / Heating
View Scheme
参考文献
Mao, Lisheng; Moriuchi, Toshiyuki; Sakurai, Hidehiro; Fujii, Hiroyuki; Hirao, Toshikazu
Tetrahedron Letters, 2005 , vol. 46, # 48 p. 8419 - 8422
