Multi-step reaction with 4 steps 1: xylene / 48 h / Heating2: 1.) NaH, DMSO / 1.) RT, 10 min, 2.) 23 h3: H2, glacial AcOH / 5 percent Pd/C / methanol / 20 h / 2280 Torr4: 2 M HCl / tetrahydrofuran / 20 h / Ambient temperature  

Multi-step reaction with 5 steps 1: Et3N / CH2Cl2 / 5 h2: xylene / 48 h / Heating3: 1.) NaH, DMSO / 1.) RT, 10 min, 2.) 23 h4: H2, glacial AcOH / 5 percent Pd/C / methanol / 20 h / 2280 Torr5: 2 M HCl / tetrahydrofuran / 20 h / Ambient temperature