(1S,7aS)-4,7a-二甲基-1-{[(2-甲基-2-丙基)(二苯基)硅烷基]氧基}-1,2,3,6,7,7a-六氢-5H-茚-5-酮合成路线 （共 5 条）
反应条件
1H-imidazole; 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
T=25°C; 4 h;
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
反应条件
1: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
2: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C
2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C
3: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
4: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
反应条件
1: 89 percent / Et3N / ethyl acetate / 12 h / 25 °C
2: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C
3: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
4: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
反应条件
1: 60 percent / D-CSA; L-Phe / acetonitrile / 120 h / 25 - 70 °C
2: 97 percent / NaBH4 / methanol / 0.5 h / 0 °C
3: 77 percent / imidazole; DMAP / dimethylformamide / 12 h / 35 °C
View Scheme
参考文献
Brady, Thomas P.; Kim, Sun Hee; Wen, Ke; Kim, Charles; Theodorakis, Emmanuel A.
Chemistry - A European Journal, 2005 , vol. 11, # 24 p. 7175 - 7190
