1-(2-氯-4-硝基苯基)-1-乙酮合成路线 （共 4 条）
反应条件
1: malonic acid dimethyl ester With triethylamine; magnesium chloride in toluene T=20°C; 1.5 h; 2: 2-chloro-4-nitro-benzoic acid chloride in toluene 0.75 h; 3: With water in dimethyl sulfoxide Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 6066 - 6083
反应条件
(i) EtNO2, NaOH, EtOH, (ii) aq. HCl; Multistep reaction;
参考文献
Chemische Berichte, , vol. 97, p. 1902 - 1909
反应条件
water; iron; ammonium chloride in ethanol 1 h; Heating / reflux;
参考文献
Bailly, Jacques; Hertel, Cornelia; Hunziker, Daniel; Lerner, Christian; Obst Sander, Ulrike; Peters, Jens-Uwe; Pflieger, Philippe; Schulz-Gasch, Tanja
Patent: US2009/88425 A1, 2009 ;
Location in patent: Page/Page column 39 ;
US 20090088425 A1
反应条件
ammonium chloride; iron in ethanol; water
参考文献
Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius
Patent: US2010/249139 A1, 2010 ;
US 20100249139 A1
