5-氯-2,4-二羟基苯甲酸甲酯合成路线 （共 5 条）
反应条件
1: With tetrabutylammomium bromide; potassium carbonate in 1-methyl-pyrrolidin-2-one T=60 - 65°C; 16 h; 2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water pH=~ 4;
参考文献
ASTRAZENECA AB
Patent: WO2009/11655 A1, 2009 ;
Location in patent: Page/Page column 38 ;
WO 2009/011655 A1
反应条件
sodium hydroxide in methanol 4 h; Heating;
参考文献
Blagg, Brian; Shen, Gang; Clevenger, Randell C.
Patent: US2006/89495 A1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
sulfuryl dichloride in dichloromethane
T=0 - 25°C; 19 h;
参考文献
Blagg, Brian; Shen, Gang; Clevenger, Randell C.
Patent: US2006/89495 A1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
1: With AlCl3, aluminium chloride; lauryl mercaptan in toluene
T=40 - 50°C; 4.75 h;
2: With water in toluene
参考文献
ASTRAZENECA AB
Patent: WO2009/11653 A1, 2009 ;
Location in patent: Page/Page column 21-22 ;
WO 2009/011653 A1
参考文献
Setalvad; Shah
Journal of the Indian Chemical Society, 1953 , vol. 30, p. 373,377
Journal of the Indian Chemical Society, 1954 , vol. 31, p. 600,603
