2,2,6,6,-四甲基哌啶-4-甲腈合成路线 （共 2 条）
反应条件
1: 2,2,6,6-tetramethyl-piperidinyl-4-one With potassium tert-butylate in ethylene glycol dimethyl ether; tert-butyl alcohol 1 h; Inert atmosphere; 2: 4-toluene-sulfonylmethyl isocyanide in ethylene glycol dimethyl ether; tert-butyl alcohol T=20°C; Inert atmosphereReflux;
参考文献
Lalonde, Judith M.; Elban, Mark A.; Courter, Joel R.; Sugawara, Akihiro; Soeta, Takahiro; Madani, Navid; Princiotto, Amy M.; Kwon, Young Do; Kwong, Peter D.; Schoen, Arne; Freire, Ernesto; Sodroski, Joseph; Smith III, Amos B.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 91 - 101
反应条件
potassium tert-butylate in ethylene glycol dimethyl ether; tert-butyl alcohol 1.) 0 deg C, 45 min; 2.) room temp., 1 h.;
参考文献
Houssin; Bernier; Henichart
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 465 - 469
