4-(2-硝基-苯基)-丁酸合成路线 （共 13 条）
反应条件
trifluorormethanesulfonic acid T=130°C; 0.75 h;
参考文献
BAYER AG
Patent: EP1369412 A1, 2003 ;
Location in patent: Page 6 ;
反应条件
hydrogenchloride 12 h; Reflux;
参考文献
Taipei Medical University
Patent: EP2388247 A2, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
1: With hydrogenchloride 12 h; Reflux; 2: With hydrogen; palladium 10 on activated carbon in methanol T=20°C; 4 h;
参考文献
Taipei Medical University
Patent: EP2388247 A2, 2011 ;
Location in patent: Page/Page column 8 ;
反应条件
sodium hydroxide; zinc
参考文献
Joensson,N.A. et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1978 , vol. 32, p. 317 - 321
反应条件
1: HCl / Heating 2: 65 percent / cyclohexene / Pd/C / ethanol / Heating View Scheme
参考文献
Gaudreault; lacroix; Page; Joly
Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 2 p. 185 - 187
反应条件
phosphoric acid in water
T=100°C; 17 h;
参考文献
BAYER AG
Patent: EP1369412 A1, 2003 ;
Location in patent: Page 5 ;
反应条件
nitric acid
6 h; Ambient temperature;
参考文献
Gaudreault; lacroix; Page; Joly
Journal of Pharmaceutical Sciences, 1988 , vol. 77, # 2 p. 185 - 187
反应条件
nitric acid in dichloromethane
24 h; Ambient temperature;
参考文献
Strazzolini, Paolo; Giumanini, Angelo G.; Runcio, Antonio; Scuccato, Massimo
Journal of Organic Chemistry, 1998 , vol. 63, # 4 p. 952 - 958
参考文献
Joensson,N.A. et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1978 , vol. 32, p. 317 - 321
反应条件
1: (i) NaH, (ii) /BRN= 389108/, (iii) aq. KOH
2: aq. H2SO4
View Scheme
参考文献
Joensson,N.A. et al.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1978 , vol. 32, p. 317 - 321
