3,4-二氢-2H-苯并[b]噁嗪-5-酮合成路线 （共 21 条）
反应条件
bromine in diethyl ether T=0 - 30°C; 2 h;
参考文献
Maiti, Swaraj B.; Ray Chaudhuri, S. R.; Chatterjee, Amareshwar
Synthesis, 1987 , # 9 p. 806 - 809
反应条件
sulfuric acid in ethyl acetate
参考文献
Hoechst Aktiengesellschaft
Patent: US5194442 A1, 1993 ;
反应条件
nitric acid T=-10°C; 0.5 h;
参考文献
Buckle, Derek R.; Eggleston, Drake S.; Houge-Frydrych, Catherina S. V.; Pinto, Ivan L.; Readshaw, Simon A.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , p. 2763 - 2772
反应条件
magnesium 1.) THF, 2.) THF a) -20 deg C to r.t., b) reflux, 4h; Yield given. Multistep reaction;
参考文献
Balasubramanian, M.; Ramadas, S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 59 - 60
反应条件
sodium methylate in benzene
参考文献
Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro; Cafaggi, Sergio
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 937 - 939
反应条件
1: 91 percent / sodium methoxide / benzene
2: 91 percent
3: 82 percent / triethylamine
View Scheme
参考文献
Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro; Cafaggi, Sergio
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 937 - 939
反应条件
1: 91 percent / sodium methoxide / benzene
2: 96 percent
3: 78 percent / triethylamine
View Scheme
参考文献
Menozzi, Giulia; Mosti, Luisa; Schenone, Pietro; Cafaggi, Sergio
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 937 - 939
反应条件
1: 5.75 g / NaOMe / benzene
2: pyridine
View Scheme
参考文献
Bhattacharya, Sudin; Mandal, Asok N.; Chaudhuri, Swadesh R. Ray; Chatterjee, Amareshwar
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 5 - 13
反应条件
1: 5.75 g / NaOMe / benzene
2: pyridine
3: 67 percent / hydrogen, triethylamine / PtO2 / propan-2-ol
4: Michael condensation
5: 3.2 g / 20percent aq. KOH
View Scheme
参考文献
Bhattacharya, Sudin; Mandal, Asok N.; Chaudhuri, Swadesh R. Ray; Chatterjee, Amareshwar
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 5 - 13
反应条件
1: 5.75 g / NaOMe / benzene
2: pyridine
3: 67 percent / hydrogen, triethylamine / PtO2 / propan-2-ol
4: Michael condensation
5: 3.2 g / 20percent aq. KOH
6: 1.) ethyl chloroformate, triethylamine, 2.) sodium azide / 1.) acetone, 0 deg C, 30 min, 2.) H2O, 0 deg C, 1 h
View Scheme
参考文献
Bhattacharya, Sudin; Mandal, Asok N.; Chaudhuri, Swadesh R. Ray; Chatterjee, Amareshwar
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 1 p. 5 - 13
