ammonium acetate in isopropyl alcohol 22 h; Heating / reflux;

acetone in toluene T=80°C; 0.333333 h; Flow reactor;

sodium tetrahydroborate in tetrahydrofuran; methanol T=0 - 20°C; 3 h; Cooling with iceInert atmosphere;

1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride; 2,6-di-tert-butyl-4-methyl-phenol / N,N-dimethyl-formamide / 18 h / 90 °C / |Inert atmosphere 2: sodium tetrahydroborate / tetrahydrofuran; methanol / 3 h / 0 - 20 °C / |Cooling with ice; |Inert atmosphere View Scheme

toluene-4-sulfonic acid in benzene 3 h; Heating;