1.1: NaH / dimethylformamide / 0.5 h 1.2: 93 percent / dimethylformamide / 4 h / 20 °C 2.1: 98 percent / LiCl*H2O; water / dimethylsulfoxide / 16 h / 150 °C 3.1: 93 percent / LiOH*H2O / H2O; ethanol / 1 h 4.1: aq. NaOH; acylase I from Aspergillus melleus / CoCl2*6H2O / aq. phosphate buffer / 48 h / 39 °C / pH 7.2 View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
1.1: NaH / dimethylformamide / 0.5 h 1.2: 93 percent / dimethylformamide / 4 h / 20 °C 2.1: 98 percent / LiCl*H2O; water / dimethylsulfoxide / 16 h / 150 °C 3.1: 93 percent / LiOH*H2O / H2O; ethanol / 1 h 4.1: aq. NaOH; acylase I from Aspergillus melleus / CoCl2*6H2O / aq. phosphate buffer / 48 h / 39 °C / pH 7.2 5.1: NaHCO3 / tetrahydrofuran / 2 h View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
1: 93 percent / K2CO3 / dimethylformamide / 20 °C
2: 92 percent / TFA / 0.75 h / 20 °C
View Scheme
参考文献
Hardouin, Christophe; Kelso, Michael J.; Romero, F. Anthony; Rayl, Thomas J.; Leung, Donmienne; Hwang, Inkyu; Cravatt, Benjamin F.; Boger, Dale L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3359 - 3368
1.1: NaH / dimethylformamide / 0.5 h
1.2: 93 percent / dimethylformamide / 4 h / 20 °C
2.1: 98 percent / LiCl*H2O; water / dimethylsulfoxide / 16 h / 150 °C
View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
1.1: NaH / dimethylformamide / 0.5 h
1.2: 93 percent / dimethylformamide / 4 h / 20 °C
2.1: 98 percent / LiCl*H2O; water / dimethylsulfoxide / 16 h / 150 °C
3.1: 93 percent / LiOH*H2O / H2O; ethanol / 1 h
View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
