1-乙酰基-4-(4-羟基苯基)哌嗪合成路线 （共 13 条）
反应条件
sodium hydride 1.) DMSO, RT, 1 h, 2.) DMSO, 80 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Camps, Pelayo; Farres, Xavier; Garcia, Luisa; Ginesta, Joan; Pascual, Jaume; et al.
Tetrahedron: Asymmetry, 1995 , vol. 6, # 6 p. 1283 - 1294
反应条件
sodium hydride in N,N-dimethyl-formamide
T=60°C;
参考文献
Silverman, Lisa S.; Caldwell, John P.; Greenlee, William J.; Kiselgof, Eugenia; Matasi, Julius J.; Tulshian, Deen B.; Arik, Leyla; Foster, Carolyn; Bertorelli, Rosalia; Monopoli, Angela; Ongini, Ennio
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1659 - 1662
反应条件
1: 80 percent / NaH / dimethylformamide / 60 °C
2: 95 percent / aq. HCl / 80 °C
View Scheme
参考文献
Silverman, Lisa S.; Caldwell, John P.; Greenlee, William J.; Kiselgof, Eugenia; Matasi, Julius J.; Tulshian, Deen B.; Arik, Leyla; Foster, Carolyn; Bertorelli, Rosalia; Monopoli, Angela; Ongini, Ennio
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 6 p. 1659 - 1662
