1-异丙基-4-(4-羟基苯基)哌嗪合成路线 （共 4 条）
反应条件
1: With acetic acid in methanol T=60°C; 0.5 h; 2: With sodium cyanoborohydride in methanol T=60°C; 16 h; 3: With hydrogenchloride; water in methanol
参考文献
GALAPAGOS N.V.
Patent: WO2008/55959 A1, 2008 ;
Location in patent: Page/Page column 67 ;
WO 2008/055959 A1
反应条件
hydrogen bromide Heating;
参考文献
Heeres, J.; Hendrickx, R.; Cutsem, J.Van
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 611 - 613
反应条件
1: H2, NaOAc / 10percent Pd/C / methanol 2: 85 percent / 48percent HBr / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 4 p. 611 - 613
反应条件
sodium hydride 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Heeres, J.; Hendrickx, R.; Cutsem, J.Van
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 611 - 613
