5-甲氧基吲哚-2-羧酸甲酯合成路线 （共 23 条）
反应条件
sulfuric acid 6 h; Reflux;
参考文献
WO2012/59776 A1, ;
Page/Page column 57 ;
WO 2012/059776 A1
反应条件
in methanol; hexane; ethyl acetate
反应条件
in toluene T=200°C; 0.166667 h; Microwave irradiation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1740 - 1742
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide 28 h; Ambient temperature;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 3 p. 507 - 514
反应条件
dirhodium(II) tetrakis(perfluorobutyrate) in toluene T=40°C; 16 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 74, # 17 p. 6442 - 6451
反应条件
1: α-acetylaminoacrylic acid With triphenylphosphine; hydroxymethyl polystyrene resin; diethylazodicarboxylate in tetrahydrofuran; toluene T=20°C; 24 h; 2: 1,2-dibromo-4-methoxybenzene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; N,N-dicyclohexylmethylamine; [(t-Bu)3PH]BF4 in toluene Heck reaction; 3: sodium methylate in tetrahydrofuran; methanol T=20°C; 12 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 15 p. 6011 - 6019
反应条件
1: sodium nitrite; hydrogenchloride / water / 1.17 h / 0 °C / |Inert atmosphere 2: sodium carbonate / water; methanol / 4 h / |Inert atmosphere 3: sodium ethanolate; ethanol / ethanol / 0.25 h / 25 - 30 °C / |Inert atmosphere 4: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 4 p. 214 - 220
反应条件
1: sodium carbonate / water; methanol / 4 h / |Inert atmosphere 2: sodium ethanolate; ethanol / ethanol / 0.25 h / 25 - 30 °C / |Inert atmosphere 3: hydrogenchloride / water / 2.25 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 4 p. 214 - 220
反应条件
1: 45 percent / methanol / -10 °C 2: 37 percent / xylene / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 25 p. 6270 - 6282
反应条件
sodium hydroxide Heating;
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
