5-甲氧基吲哚-2-羧酸甲酯合成路线 （共 23 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.75 h; Ambient temperature;
参考文献
Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Mor, Marco; Plazzi, Pier Vincenzo; Rivara, Silvia; Nonno, Romolo; Pannacci, Marilou; Lucini, Valeria; Fraschini, Franco; Stankov, Bojidar Michaylov
Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3624 - 3634
反应条件
1: LiAlH4 / tetrahydrofuran / 0.75 h / Ambient temperature 2: MnO2 / CH2Cl2 / 7 h / Ambient temperature View Scheme
参考文献
Spadoni, Gilberto; Balsamini, Cesarino; Bedini, Annalida; Diamantini, Giuseppe; Di Giacomo, Barbara; Tontini, Andrea; Tarzia, Giorgio; Mor, Marco; Plazzi, Pier Vincenzo; Rivara, Silvia; Nonno, Romolo; Pannacci, Marilou; Lucini, Valeria; Fraschini, Franco; Stankov, Bojidar Michaylov
Journal of Medicinal Chemistry, 1998 , vol. 41, # 19 p. 3624 - 3634
反应条件
1: 99 percent / aq. NaOH / Heating 2: 77 percent / Cu; quinoline / Heating 3: 90 percent / phosphoryl chloride / 0 - 40 °C View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1: 99 percent / aq. NaOH / Heating 2: 77 percent / Cu; quinoline / Heating View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 65 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 62 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 83 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 84 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 94 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 91 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
反应条件
1.1: 99 percent / aq. NaOH / Heating
2.1: 77 percent / Cu; quinoline / Heating
3.1: 90 percent / phosphoryl chloride / 0 - 40 °C
4.1: NaOH / CH2Cl2 / 20 °C
4.2: 95 percent / CH2Cl2 / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 0 °C
5.2: potassium tert-butoxide / tetrahydrofuran; hexane / 0 °C
5.3: 71 percent / tetrahydrofuran; hexane / -78 - 0 °C
6.1: 94 percent / H2 / Pd/C / ethanol / 20 °C / 760 Torr
View Scheme
参考文献
Coowar, Djalil; Bouissac, Julien; Hanbali, Mazen; Paschaki, Marie; Mohier, Eliane; Luu, Bang
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6270 - 6282
