2-氯-5,6,7,8-四氢-吡啶并[2,3-b]氮杂卓-9-羧酸叔丁酯合成路线 （共 4 条）
反应条件
1: 1,1-dimethylethyl[6-chloro-2-pyridinyl]carbamate With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 1-chloro-4-iodo-butane With copper(l) iodide in tetrahydrofuran
9 h; Heating; Further stages.;
参考文献
Davies, Antony J.; Brands, Karel M. J.; Cowden, Cameron J.; Dolling, Ulf-H.; Lieberman, David R.
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1721 - 1724
反应条件
1: 1,1-dimethylethyl[6-chloro-2-pyridinyl]carbamate With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane
T=-78°C;
2: 1-bromo-4-chloro-butane in tetrahydrofuran
Heating; Further stages.;
参考文献
Davies, Antony J.; Brands, Karel M. J.; Cowden, Cameron J.; Dolling, Ulf-H.; Lieberman, David R.
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1721 - 1724
反应条件
1: 91 percent / hexyllithium; 1,1,1,3,3,3-hexamethyldisilazane / tetrahydrofuran / 0.5 h / 20 °C
2: 78 percent / hexyllithium; N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran / 9 h / Heating
View Scheme
参考文献
Keen, Stephen P.; Cowden, Cameron J.; Bishop, Brian C.; Brands, Karel M. J.; Davies, Antony J.; Dolling, Ulf H.; Lieberman, David R.; Stewart, Gavin W.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1771 - 1779
反应条件
1: 91 percent / hexyllithium; 1,1,1,3,3,3-hexamethyldisilazane / tetrahydrofuran / 0.5 h / 20 °C
2: 78 percent / hexyllithium; N,N,N',N'-tetramethylethylenediamine / hexane; tetrahydrofuran / 9 h / Heating
View Scheme
参考文献
Keen, Stephen P.; Cowden, Cameron J.; Bishop, Brian C.; Brands, Karel M. J.; Davies, Antony J.; Dolling, Ulf H.; Lieberman, David R.; Stewart, Gavin W.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1771 - 1779
