4-苯基-1,3-二氢-2H-咪唑-2-酮合成路线 （共 16 条）
反应条件
1: 67 percent / HCl conc. / ethanol / 2 h / Heating
2: 83 percent / aq. ammonia / methanol / 3 h / Heating
View Scheme
参考文献
Shvaika, O. P.; Korotkikh, N. I.; Chervinskii, A. Yu.; Artemov, V. N.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 8 p. 1533 - 1543
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 8 p. 1728 - 1739
反应条件
1: 1)KOH, 2)tetraethylammonium chloride / 1) methanol, 60 deg C, 10 - 15 min and methanol distilled out, 2) CHCl3, heating 1h
2: 83 percent / aq. ammonia / methanol / 3 h / Heating
View Scheme
参考文献
Shvaika, O. P.; Korotkikh, N. I.; Chervinskii, A. Yu.; Artemov, V. N.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 8 p. 1533 - 1543
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 8 p. 1728 - 1739
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Wilk; Close
Journal of Organic Chemistry, 1950 , vol. 15, p. 1020
反应条件
ammonium hydroxide; bromine; acetic acid
1) 18-20 deg C, 2) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Zav'yalov, S. I.; Sitkareva, I. V.; Ezhova, G. I.; Dorofeeva, O. V.; Zavonin, A. G.; Rumyantseva, E. E.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 6 p. 708
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , # 6 p. 847 - 848
反应条件
acetic acid; lithium tert-butylate
1) -70 deg C, THF, hexane; 2) room temperature; Yield given. Multistep reaction;
参考文献
Schoellkopf, Ulrich; Lau, Hans-Hermann; Scheunemann, Karl-Heinz; Blume, Ernst; Madawinata, Kusuma
Liebigs Annalen der Chemie, 1980 , # 4 p. 600 - 610
反应条件
1: platinum; acetic acid / Hydrogenation
View Scheme
参考文献
Wilk; Close
Journal of Organic Chemistry, 1950 , vol. 15, p. 1020
