bromine in N,N,N',N',N'',N''-hexamethylphosphoric triamide; ice-water; diethyl ether; water; acetic acid; ethyl acetate; mineral oil

bromine in acetic acid 2 h; Ambient temperature;

1: diisopropylamin, n-butyllithium (15 percent), / hexane; tetrahydrofuran / 1 h / -78 °C 2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / Ambient temperature; stirring overnight 3: 82 percent / brom / acetic acid / 2 h / Ambient temperature View Scheme

1: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / Ambient temperature; stirring overnight 2: 82 percent / brom / acetic acid / 2 h / Ambient temperature View Scheme

1: diisopropylamin, n-butyllithium (15 percent), / hexane; tetrahydrofuran / 1 h / -78 °C 2: tetrabutylammoniumfluorid-hydrat / hexane; tetrahydrofuran; CH2Cl2 / Ambient temperature; stirring overnight 3: 82 percent / brom / acetic acid / 2 h / Ambient temperature View Scheme

potassium acetate in hydrogenchloride; acetic anhydride

bromine; sodium ethanolate in ethanol; acetic acid