反应条件
1: 83 percent / H2SO4 / benzene / 36 h / Heating
2: 59 percent / LAH / diethyl ether; tetrahydrofuran / 48 h / Heating
3: 48percent HBr, H2SO4 / 24 h / Heating
4: 1.) NaOEt / 1.) EtOH, reflux, 15 min, 2.) EtOH, reflux, 24 h
5: 78 percent / KOH / ethanol / 2 h / Heating
6: 85 percent / 1 h / 200 °C
7: SOCl2 / CH2Cl2 / 24 h / Heating
View Scheme
参考文献
Scott; Moore; Zalucky; Nicholson; Lee; Hinko
Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 413 - 417