(4-溴苯氧基)叔丁基二甲基硅烷合成路线 （共 45 条）
反应条件
1.1: sodium carbonate / water; ethanol; toluene / 0.5 h / |Inert atmosphere 1.2: |Inert atmosphere; |Reflux 2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C View Scheme
参考文献
Dahlgren, Markus K.; Garcia, Alvaro Baeza; Hare, Alissa A.; Tirado-Rives, Julian; Leng, Lin; Bucala, Richard; Jorgensen, William L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10148 - 10159
反应条件
1: 56 percent / Mg / tetrahydrofuran / 20 °C 2: 90 percent / TBAF / tetrahydrofuran / 20 °C View Scheme
参考文献
Kan, Jovi Tze Wai; Toy, Patrick
Tetrahedron Letters, 2004 , vol. 45, # 33 p. 6357 - 6359
反应条件
cesium fluoride in N,N-dimethyl-formamide 3 h; Ambient temperature;
参考文献
Oriyama, Takeshi; Noda, Kojiro; Yatabe, Kaori
Synlett, 1997 , vol. 1997, # 6 p. 701 - 703
反应条件
1.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C 1.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C 1.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C 2.1: 91 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
1.1: n-butyl lithium / tetrahydrofuran / 0.5 h / -78 °C
1.2: triisopropyl borate / tetrahydrofuran / -78 - 20 °C
1.3: 65 percent / HCl / tetrahydrofuran; H2O / 0.08 h / 0 °C
2.1: 91 percent / Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 95 °C
View Scheme
参考文献
Edsall Jr., Richard J; Harris, Heather A; Manas, Eric S; Mewshaw, Richard E
Bioorganic and medicinal chemistry, 2003 , vol. 11, # 16 p. 3457 - 3474
反应条件
P(i-BuNCH2CH2)3N in toluene
T=130°C; 0.5 h; microwave irradiation;
参考文献
Raders, Steven M.; Verkade, John G.
Tetrahedron Letters, 2008 , vol. 49, # 21 p. 3507 - 3511
反应条件
1.1: n-BuLi / various solvent(s); tetrahydrofuran / 0.5 h / -78 °C
1.2: 92 percent / tetrahydrofuran; various solvent(s) / -78 - 20 °C
2.1: 52 percent / Na2CO3; LiCl / Pd(PPh3)4 / 1,2-dimethoxy-ethane; H2O / 2 h / Heating
3.1: 92 percent / AD-mix-α; CH3SO2NH2 / 2-methyl-propan-2-ol; H2O / 0 - 20 °C
4.1: TBAF / tetrahydrofuran / 0 - 20 °C
5.1: 1.10 g / Raney Ni / ethanol / 4 h / Heating
View Scheme
参考文献
Bursavich; West; Rich
Organic letters, 2001 , vol. 3, # 15 p. 2317 - 2320
反应条件
cesium fluoride in N,N-dimethyl-formamide
12 h; Ambient temperature;
参考文献
Oriyama, Takeshi; Noda, Kojiro; Yatabe, Kaori
Synlett, 1997 , vol. 1997, # 6 p. 701 - 703
反应条件
1: 64 percent / diisopropylamine; tri(tert-butyl)phosphane; CuI / PdCl2(PhCN)2 / dioxane / 20 h / 20 °C
2: AgNO3 / acetone; H2O / 44 h / 20 °C
View Scheme
参考文献
Carpita, Adriano; Mannocci, Luca; Rossi, Renzo
European Journal of Organic Chemistry, 2005 , # 9 p. 1859 - 1864
反应条件
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; ethanol; toluene / |Inert atmosphere; |Reflux
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Dahlgren, Markus K.; Garcia, Alvaro Baeza; Hare, Alissa A.; Tirado-Rives, Julian; Leng, Lin; Bucala, Richard; Jorgensen, William L.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10148 - 10159
