toluene-4-sulfonic acid in benzene 20 h; Heating;

1: 72 percent / CuI / Pd(PPh3)2Cl2 / triethylamine / 20 h / 100 °C 2: 63 percent / methanol / 5 h / Heating 3: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 4: 72 percent / TsOH / benzene / 20 h / Heating View Scheme

1: 63 percent / methanol / 5 h / Heating 2: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 3: 72 percent / TsOH / benzene / 20 h / Heating View Scheme

1: 61 percent / 3N Na2CO3, 15percent H2O2 / acetone / 6 h / Ambient temperature 2: 72 percent / TsOH / benzene / 20 h / Heating View Scheme

meta-nitrobenzenesulfonic acid T=145°C;