4-吡咯烷-1-基苯甲酰基氯化物合成路线 （共 6 条）
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,146
反应条件
1-methyl-pyrrolidin-2-one; thionyl chloride in dichloromethane
T=20°C;
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397
反应条件
1: thionyl chloride / -10 - 20 °C
2: potassium carbonate; tBuNH2·BH3 / 1,4-dioxane; water / 48 h / |Reflux
3: sodium hydroxide; water / methanol / |Reflux
4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C
View Scheme
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
1: potassium carbonate; tBuNH2·BH3 / 1,4-dioxane; water / 48 h / |Reflux
2: sodium hydroxide; water / methanol / |Reflux
3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C
View Scheme
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
1: sodium hydroxide; water / methanol / |Reflux
2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C
View Scheme
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,146
