silver carbonate; bis[2-(diphenylphosphino)phenyl] ether; palladium (II) bromide in N,N-dimethyl acetamide; toluene T=150°C; 1 h; Microwave irradiationInert atmosphere;

1: With lithium hydroxide hydrate; water in 1,4-dioxane T=20°C; 24 h; 2: With citric acid in water

potassium hydroxide T=90°C; 20 h;

T=120°C; 4 h;

1.1: acetic anhydride; sodium hydrogencarbonate / 20 - 100 °C 2.1: acetic acid / 20 - 80 °C 2.2: 5 h / 80 - 100 °C 3.1: sodium hydride / N,N-dimethyl-formamide; ethylene glycol dimethyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere 3.2: 0.25 h / 20 °C 3.3: 3 h / 20 - 60 °C 4.1: water; lithium hydroxide hydrate / 1,4-dioxane / 24 h / 20 °C View Scheme

1.1: acetic acid / 20 - 80 °C 1.2: 5 h / 80 - 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide; ethylene glycol dimethyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere 2.2: 0.25 h / 20 °C 2.3: 3 h / 20 - 60 °C 3.1: water; lithium hydroxide hydrate / 1,4-dioxane / 24 h / 20 °C View Scheme

1.1: sodium hydride / N,N-dimethyl-formamide; ethylene glycol dimethyl ether; mineral oil / 0.25 h / 20 °C / Inert atmosphere 1.2: 0.25 h / 20 °C 1.3: 3 h / 20 - 60 °C 2.1: water; lithium hydroxide hydrate / 1,4-dioxane / 24 h / 20 °C View Scheme