N-(2-氨基-4-氯苯)邻氨基苯甲酸合成路线 （共 16 条）
反应条件
hydrogen; platinum on sulfide coal in ethyl acetate P=1500.15 Torr; 5 h;
参考文献
AKZO NOBEL N.V.
Patent: WO2003/84963 A1, 2003 ;
Location in patent: Page/Page column 18; 65 ;
WO 03/084963 A1
反应条件
1: K2CO3 / dimethylformamide / 140 °C 2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / Heating View Scheme
参考文献
Pharmazie, , vol. 45, # 8 p. 555 - 559
反应条件
1: 74 percent / K2CO3; Cu / various solvent(s) / 4 h / Heating 2: 64 percent / Na2S2O4 / aq. NH3 / 80 °C View Scheme
参考文献
Australian Journal of Chemistry, , vol. 55, # 9 p. 565 - 576
反应条件
1: K2CO3 / dimethylformamide / 140 °C 2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / Heating View Scheme
参考文献
Pharmazie, , vol. 45, # 8 p. 555 - 559
反应条件
1: hydrogenchloride / water / 2 h / |Reflux 2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 3: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 2: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; sulfuric acid / 2 h / 70 °C 2: potassium permanganate; water / 8 h / |Reflux 3: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 4: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C 5: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 6: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium permanganate; water / 8 h / |Reflux 2: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 3: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C 4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 5: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 2: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C 3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 4: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 2: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
