N-(2-氨基-4-氯苯)邻氨基苯甲酸合成路线 （共 16 条）
反应条件
1: dichloromethane / 1 h / 20 °C 2: nitric acid; acetic acid / 0.5 h / 0 °C 3: hydrogenchloride / water / 2 h / |Reflux 4: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 5: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; acetic acid / 0.5 h / 0 °C 2: hydrogenchloride / water / 2 h / |Reflux 3: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C 4: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux View Scheme
参考文献
Letters in Drug Design and Discovery, , vol. 10, # 4 p. 369 - 373
参考文献
Sasikumar; Burnett; Zhang; Smith-Torhan; Fawzi; Lachowicz
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 17 p. 4543 - 4547
反应条件
1: 96 percent / xylene / Heating 2: 53 percent / TiCl4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4543 - 4547
反应条件
1: conc. H3PO4 / xylene / 140 °C
2: 90 percent / xylene / Heating
3: dimethylformamide / 8 h / Ambient temperature
View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
1: 79 percent / xylene / 96 h / Heating
2: 69 percent / TiCl4 / dioxane / 24 h / Heating
View Scheme
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
